There is the possibly that Almighty God could get so angry with the world, that He becomes dead set on destroying men and not even His most faithful servants will be able to change His mind.
The word of the Lord came to me: Mortal, when a land sins against me by acting faithlessly and I stretch out my hand against it and break its staff of bread and send famine upon it and cut off from it human beings and animals. Even if Noah, Daniel,[a Job, these three, were in it, they would save only their own lives by their righteousness says the Lord God. If I send wild animals through the land to ravage it, so that it is made desolate, and no one may pass through because of the animals; Even if these three men were in it says the Lord God. They would save neither sons nor daughters; they alone would be saved, but the land would be desolate. Or if I bring a sword upon that land and say, “Let a sword pass through the land,” and I cut off human beings and animals from it; Though these three men were in it says the Lord God, they would save neither sons nor daughters, but they alone would be saved. Or if I send a pestilence into that land, and pour out my wrath upon it with blood, to cut off humans and animals from it; If Noah, Daniel,[b] and Job were in it, says the Lord God, they would save neither son nor daughter; they would save only themselves by their righteousness. Ez 14.12-20